Phorbol ester-induced disruption of the CD4-Lck complex occurs within a detergent-resistant microdomain of the plasma membrane. Involvement of the translocation of activated protein kinase C isoforms.
Parolini I, Topa S, Sorice M, Pace A, Ceddia P, Montesoro E, Pavan A, Lisanti MP, Peschle C, Sargiacomo M.
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J Biol Chem. 1999 May 14;274(20):14176-87. doi: 10.1074/jbc.274.20.14176.
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PMID: 10318836
Free article.
In hematopoietic cells, these low density Triton-insoluble (LDTI) microdomains (also called caveolae-related domains) are dramatically enriched in signaling molecules, such as cell surface receptors (CD4 and CD55), Src family tyrosine kinases (Lyn, Lck, Hck, and Fyn …
In hematopoietic cells, these low density Triton-insoluble (LDTI) microdomains (also called caveolae-related domains) are dramatically enric …